Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis.
Morbi-mortality in cystic fibrosis (CF) is mainly related to chronic lung infection and inflammation, uncontrolled g5210t-p90 tissue rearrangements and fibrosis, and yet the underlying mechanisms remain largely unknown.We evaluated inflammatory and fibrosis responses to bleomycin in F508del homozygous and wild-type mice, and phenotype of fibroblast